PROSPER
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Program of Optimal and Safe Prescribing in the EldeRly (PROSPER)​

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

Our Mission 

The mission of the Program of Optimal and Safe Prescribing in the EldeRly (PROSPER)​ it to generate high-quality comparative safety and effectiveness real-world evidence for optimal prescribing and deprescribing in older adults based on validated patient phenotyping and detailed treatment effect heterogeneity assessment
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What We Do

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NIH-Funded National Studies

  • A targeted analytical framework to optimize posthospitalization delirium pharmacotherapy in patients with Alzheimer’s disease and related dementias (NIA R01 AG081412, 2023-2027)
  • Deprescribing antipsychotics in patients with Alzheimer’s disease and related dementias and behavioral disturbance in skilled nursing facilities (NIA R01 AG081268, 2023-2027)
  • Effectiveness and Safety of Transcatheter Left Atrial Appendage Occlusion vs. Anticoagulation in Older Adults with Atrial Fibrillation and Alzheimer's Disease and Related dementias (NIA R01 AG075335, 2022-2026)
  • Assessing the effectiveness of oral anticoagulants in patients with atrial fibrillation at high risk of underutilization due to dementia, recurrent falls, or poor anticoagulation quality (NIA RF1 AG063381, 2019-2023)
  • Developing dynamic prognostic and risk-stratification models for informing prescribing decisions in older adults with Coronavirus Disease (NIA RF1 AG063381, 2021-2023)
  • ​Developing scalable algorithms to incorporate unstructured electronic health records for causal inference based on real-world data (NLM R01 LM013204, 2020-2025)

Selected Research Output

  • ​Development of claims-based frailty phenotyping algorithms
    • J Gerontol A Biol Sci Med Sci. 2018, PMID: 29244057
    • J Gerontol A Biol Sci Med Sci. 2020, PMID: 31566201
  • Comparative safety and effectiveness in older adults with treatment effect heterogeneity evaluation by frailty and dementia status
    • Ann Intern Med 2021, PMID: 34280330
    • JAMA Netw Open. 2023, PMID: 36976562
    • JAMA Netw Open. 2023, PMID: 36800180
  • COVID-19 pharmacotherapy in older adults and prognostic algorithm development
    • Drugs. 2020, PMID: 33151482
    • J Clin Epidemiol. 2022, PMID: 35868493
    • Clin Pharmacol Ther 2023, PMID: 37342987
    • Pharmacoepidemiol Drug Saf. 2023, PMID: 36464785
  • Development of claims-based phenotyping models for high-risk features
    • J Am Heart Assoc. 2017, PMID: 28982676
    • Am J Epidemiol. 2023, PMID: 37650647
    • Clin Epidemiol. 2023 PMID: 36919110
  • Development of high-validity analytic solutions for integrated databases needed for geriatric pharmacoepidemiology
    • Epidemiology 2018, PMID: 29283893
    • Clin Pharmacol Ther. 2022, PMID: 34424534
    • J Am Med Inform Assoc. 2022 PMID: 35357470​
Program of Optimal and Safe Prescribing in the EldeRly (PROSPER)
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Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School


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  • Our Team
  • Funding
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