Comparative safety and effectiveness in older adults:
Drug or medical device utilization in older adults:
Clinical phenotyping and prediction model development:
Aging research method development:
- Clark C, Adler R, Xiang L, Shah S, Cooper Z, Kim DH, Lin KJ, Hsu J, Lipsitz S, Weissman J. Outcomes for Patients with Dementia Undergoing Emergency and Elective Colorectal Surgery: a large multi-institutional comparative cohort study. Am J Surg. 2023 Jul;226(1):108-14.
- Fu EL, Mastrorilli J, Bykov K, Wexler DJ, Cervone A, Lin KJ, Patorno E, Paik JM. A population-based cohort defined risk of hyperkalemia after initiating SGLT-2 inhibitors, GLP1 receptor agonists or DPP-4 inhibitors to patients with chronic kidney disease and type 2 diabetes. Kidney Int. 2023 Dec 13:S0085-2538(23)00865-7. doi: 10.1016/j.kint.2023.11.025. Online ahead of print.PMID: 38101515
- Lin KJ, Singer DE, Ko D, Glynn R, Najafzadeh M, Lee SB, Bessette LG, Cervone A, DiCesare E, Kim DH. Frailty, Home Time, and Health Care Costs in Older Adults With Atrial Fibrillation Receiving Oral Anticoagulants. JAMA Netw Open. 2023 Nov 1;6(11):e2342264. doi: 10.1001/jamanetworkopen.2023.42264.PMID: 37943558
- Fu EL, Desai RJ, Paik JM, Kim DH, Zhang Y, Mastrorilli JM, Cervone A, Lin KJ. Comparative Safety and Effectiveness of Warfarin or Rivaroxaban Versus Apixaban in Patients With Advanced CKD and Atrial Fibrillation: Nationwide US Cohort Study. Am J Kidney Dis. 2023 Oct 13:S0272-6386(23)00859-4. doi: 10.1053/j.ajkd.2023.08.017. Online ahead of print. PMID: 37839687
- Wang SV, Schneeweiss S; RCT-DUPLICATE Initiative; Franklin JM, Desai RJ, Feldman W, Garry EM, Glynn RJ, Lin KJ, Paik J, Patorno E, Suissa S, D'Andrea E, Jawaid D, Lee H, Pawar A, Sreedhara SK, Tesfaye H, Bessette LG, Zabotka L, Lee SB, Gautam N, York C, Zakoul H, Concato J, Martin D, Paraoan D, Quinto K. Emulation of Randomized Clinical Trials with Nonrandomized Database Analyses: Results of 32 Clinical Trials. JAMA. 2023 Apr 25;329(16):1376-85.
- Merola D, Young J, Schrag D, Lin KJ, Alwardt S, Schneeweiss S. Effectiveness research in oncology with electronic health record data: A retrospective cohort study emulating the PALOMA-2 trial. Pharmacoepidemiol Drug Saf. 2023 Apr;32(4):426-34. doi: 10.1002/pds.5565.
- Lin KJ, Singer DE, Bykov K., Bessette LG, Mastrorilli JM, Cervone A, Kim DH. Comparative Effectiveness and Safety of Oral Anticoagulants by Dementia Status in Older Patients With Atrial Fibrillation. JAMA Netw Open. 2023 Mar 1;6(3):e234086.
- Lin KJ, Feldman WB, Wang S, Umarje S, D'Andrea E, Tesfaye H, Zabotka LE, Liu J, Desai RJ. Gastrointestinal prophylaxis for COVID-19: An illustration of severe bias arising from inappropriate comparators in observational studies. J Clin Epidemiol. 2022 Nov;151:45–52.
- Merola D, Young J, Schrag D, Lin KJ, Alwardt S, Schneeweiss S, Oncology drug effectiveness from electronic health record data calibrated against RCT evidence: The PARSIFAL trial emulation. Clin Epidemiol. 2022 Oct 10;14:1135-44.
- Fralick M, Colacci M, Schneeweiss S, Huybrechts KF, Lin KJ, Gagne JJ. Effectiveness and Safety of Apixaban Compared With Rivaroxaban for Patients With Atrial Fibrillation in Routine Practice: A Cohort Study. Ann Intern Med. 2020 Apr 7;172(7):463-73.
Drug or medical device utilization in older adults:
- Lin KJ, Singer DE, Avorn J, Heist EK, Sreedhara SK, Anand P, Zhang Y, Tsacogianis TN Schneeweiss S. Patient characteristics associated with using transcatheter left atrial appendage occlusion vs. oral anticoagulants for atrial fibrillation. Circulation: Cardiovascular Quality and Outcomes 2024 (in press)
- Ko D, Lin KJ, Bessette LG, Cervone A, Lee SB, Pande A, Cheng S, Tsacogianis T, Glynn RJ, Kim DH. Utilization of P2Y12 Inhibitors in Older Adults with ST-Elevation Myocardial Infarction and Frailty. Am J Cardiol. 2023 Nov 15:207:245-252. doi: 10.1016/j.amjcard.2023.08.059. Epub 2023 Sep 25.
- Lee YC, Lin KJ, Ko D, Cheng S, Patorno E, Glynn RJ, Tsacogiania T, Kim DH. Frailty and Uptake of Angiotensin Receptor Neprilysin Inhibitor for Heart Failure with Reduced Ejection Fraction. J Am Geriatr Soc. 2023 Jun 22. doi: 10.1111/jgs.18481. Online ahead of print.
- Simon TG, Schneeweiss S, Singer DE, Kattinakere Sreedhara S, Lin KJ. Prescribing Trends of Oral Anticoagulants in U.S. Patients with Cirrhosis and Nonvalvular Atrial Fibrillation. J Am Heart Assoc. 2023 Feb 7;12(3):e026863. PMID: 36625307
- Zhang Y, Wilkins JM, Bessette LG, York C, Wong V, Lin KJ. Antipsychotic Medication Use Among Older Adults Following Infection-Related Hospitalization. JAMA Netw Open. 2023 Feb; 6(2): e230063.
- Ko K, Lin KJ, Bessette LG, Lee SB, Walkey AJ, Cheng S, Kim E, Glynn RJ, Kim DH. Trends in Use of Oral Anticoagulants in Older Adults with Newly Diagnosed Atrial Fibrillation, 2010-2020. JAMA Netw Open. 2022 Nov 1;5(11):e2242964.
- Shah SK, Adler RR, Xiang L, Clark CJ, Cooper Z, Finlayson E, Kim DH, Lin KJ, Lipsitz SR, Weissman JS. Patients living with dementia have worse outcomes when undergoing high-risk procedures. J Am Geriatr Soc. 2022 Oct;70(10):2838-46. doi: 10.1111/jgs.17893.
- Lin KJ, Schneeweiss S, Tesfaye H, D'Andrea E, Liu J, Lii J, Murphy SN, Gagne JJ. Pharmacotherapy for Hospitalized Patients with COVID-19: Treatment Patterns by Disease Severity. Drugs. 2020 Dec;80(18):1961-72. doi: 10.1007/s40265-020-01424-7.
- Lin KJ, Dvorin E, Kesselheim AS. Prescribing systemic steroids for acute respiratory tract infections in United States outpatient settings: A nationwide population-based cohort study. PLoS Med. 2020 Mar;17(3):e1003058. doi: 10.1371/journal.pmed.1003058.
Clinical phenotyping and prediction model development:
- Suissa K, Lu Z, Bessette LG, York C, Wyss R, Lin KJ. Claims-based model to predict obesity in older patients, Am J Epidemiol. 2024 Jan 8;193(1):203-213. doi: 10.1093/aje/kwad178.
- Park CM, Sison SDM, McCarthy EP, Shi S, Gouskova N, Lin KJ, Kim DH. Claims-Based Frailty Index as a Measure of Dementia Severity in Medicare Claims Data. J Gerontol A Biol Sci Med Sci. 2023 Oct 28;78(11):2145-2151. doi: 10.1093/gerona/glad166. PMID: 37428879
- Sison SD, Lin KJ, Najafzadeh M, Ko D, Patorno E, Bessette LG, Zakoul H, Kim DH, Common Non-Cardiovascular Multimorbidity Groupings and Clinical Outcomes in Older Adults with Major Cardiovascular Disease. J Am Geriatr Soc. 2023 June 24. doi: 10.1111/jgs.18479. Online ahead of print.
- Sarri G, Liu W, Zabotka L, Freitag A, Claire R, Wangge G, Elvidge J, Dawoud D, Bennett D, Wen X, Li X, Rentsch CT, Uddin J, Ali S, Gokhale M, Déruaz-luyet A, Moga DC, Guo JJ, Zullo AR, Lin KJ. Prognostic factors of COVID-19: an Umbrella Review of Published Systematic Reviews from the International Society for Pharmacoepidemiology (ISPE) Comparative Effectiveness Research Special Interest Group. Clin Pharmacol Ther 2023 Jun 21. doi: 10.1002/cpt.2977. Online ahead of print.
- Lin KJ, Elvira D'Andrea MD, MPH; Rishi J. Desai, Joshua J. Gagne, Jun Liu, Shirley V. Wang. Prospective validation of a dynamic prognostic model for identifying COVID-19 patients at high risk of rapid deterioration. Pharmacoepidemiol Drug Saf. 2023 May;32(5):545-57. doi: 10.1002/pds.5580.
- Simon TG, Schneeweiss S, Wyss R, Lu Z, Bessette LG, York C, Lin KJ. Development and Validation of a Novel Tool to Predict Model for End-Stage Liver Disease (MELD) Score in Cirrhosis, using Administrative Datasets. Clin Epidemiol. 2023 Mar 14;15:349-62. doi: 10.2147/CLEP.S387253. eCollection 2023.
- Mansour O, Paik JM, Wyss R, Mastrorilli JM, Bessette LG, Lu A, Tsacogianis T, Lin KJ. A novel chronic kidney disease phenotyping algorithm using combined electronic health record and claims data. Clin Epidemiol. 2023 Mar 8;15:299-307. doi: 10.2147/CLEP.S397020.
- Suissa K, Schneeweiss S, Lin KJ, Brill G, Kim SC, Patorno E. Validation of obesity-related diagnosis codes in claims data. Diabetes Obes Metab. 2021 Dec;23(12):2623-31. doi: 10.1111/dom.14512. Epub 2021 Aug 18. PMID: 34338404
- Lee MP, Glynn RJ, Schneeweiss S, Lin KJ, Patorno E, Barberio J, Levin R, Evers T, Wang SV, Desai RJ. Risk Factors for Heart Failure with Preserved or Reduced Ejection Fraction Among Medicare Beneficiaries: Application of Competing Risks Analysis and Gradient Boosted Model. Clin Epidemiol. 2020;12:607-16.
- Connolly JG, Gagne JJ, Lin KJ. Evaluating the impact of increasing allowable inpatient diagnoses in Medicare claims data. [research letter] Epidemiology. 2020 Mar;31(2):e11-e12.
- Desai RJ, Lin KJ, Patorno E, Barberio J, Lee M, Levin R, Evers T, Wang SV, Schneeweiss S. Development and Preliminary Validation of a Medicare Claims-Based Model to Predict Left Ventricular Ejection Fraction Class in Patients with Heart Failure. Circ Cardiovasc Qual Outcomes. 2018 Dec;11(12):e004700.
- Lin KJ, Singer DE, Glynn RJ, Blackley S, Zhou L, Liu J, Dube G, Oertel LB, Schneeweiss S. Prediction score for anticoagulation control quality among older adults. J Am Heart Assoc. 2017 Oct 5;6(10):e006814. doi: 10.1161/JAHA.117.006814.
Aging research method development:
- Wyss R, van der Laan M, Gruber S, Shi X, Lee H, Dutcher SK, Nelson JC, Toh S, Wang SV, Desai RJ, Lin KJ. Targeted Learning with the Collaborative Controlled Lasso for Large-Scale Covariate Adjustment in Healthcare Database Studies. American Journal of Epidemiology 2024 (in press)
- Anand P, Zhang Y, Merola D, Jin Y, Wang SV, Lii J, Liu J, Lin KJ. Comparison of EHR data-completeness in patients with different types of medical insurance coverage in the United States. Clin Pharmacol Ther. 2023 Nov;114(5):1116-1125. doi: 10.1002/cpt.3027. Epub 2023 Sep
- Kar S, Bessette LG, Wyss R, Kesselheim AS, Lin KJ. The Impact of Electronic Health Record Discontinuity on Prediction Modeling. PLOS One. 2023 Jul 6;18(7):e0287985. doi: 10.1371/journal.pone.0287985.
- Jin Y, Weberpals JG, Wang SV, Desai RJ, Merola D, Lin KJ. The impact of longitudinal data-completeness of electronic health record data on the prediction performance of clinical risk scores. Clin Pharmacol Ther. 2023 Jun;113(6):1359-67
- Wyss R., Plasek JM, Zhou L, Bessett LG, Schneeweiss S, Rassen JA, Tsacogianis T, Lin KJ. Scalable feature engineering from electronic free text notes to supplement confounding adjustment of claims-based pharmacoepidemiologic studies. Clin Pharmacol Therap. 2023 Apr;113(4):832-8.
- Merola D, Schneeweiss S, Young J, Schrag D, Lii J, Lin KJ. An algorithm to predict data completeness in oncology electronic health records for comparative effectiveness research. Ann Epidemiol. 2022 Dec;76:143-9.
- Merola D, Schneeweiss S, Jin Y, Lii J, Lin KJ. Advancing an algorithm for the identification of patients with high data-continuity in electronic health records. Clin Epidemiol. 2022 Nov 8;14:1339-49. PMID: 36387928
- Wyss R, Schneeweiss S, Lin KJ, Miller DP, Kalilani L, Franklin JM. Synthetic Negative Controls: Using Simulation to Screen Large-scale Propensity Score Analyses. Epidemiology. 2022 Jul 1;33(4):541-50. PMID: 35439779; PubMed Central PMCID: PMC9156547.
- Jin Y, Schneeweiss S, Merola D, Lin KJ. Impact of longitudinal data-completeness of electronic health record data on risk score misclassification. J Am Med Inform Assoc. 2022 Jun 14;29(7):1225-32. doi: 10.1093/jamia/ocac043.
- Lin KJ, Schneeweiss S, Pawar A, Singer DE, Liu J, Gagne JJ. Using a Simple Prescription Gap to Determine Warfarin Discontinuation Can Lead to Substantial Misclassification. Thromb Haemost. 2022 Mar;122(3):386-93. doi: 10.1055/a-1508-8187.
- Lin KJ, Jin Y, Gagne JJ, Glynn RJ, Murphy SN, Tong A, Schneeweiss S. Longitudinal Data Discontinuity in Electronic Health Records and Consequences for Medication Effectiveness Studies. Clin Pharmacol Ther. 2022 Jan;111(1):243-51. doi: 10.1002/cpt.2400.
- Desai RJ, Levin R, Lin KJ, Patorno E. Bias Implications of Outcome Misclassification in Observational Studies Evaluating Association Between Treatments and All-Cause or Cardiovascular Mortality Using Administrative Claims. J Am Heart Assoc. 2020 Sep;9(17):e016906. doi: 10.1161/JAHA.120.016906.
- Lin KJ, Rosenthal GE, Murphy SN, Mandl KD, Jin Y, Glynn RJ, Schneeweiss S. External Validation of an Algorithm to Identify Patients with High Data-Completeness in Electronic Health Records for Comparative Effectiveness Research. Clin Epidemiol. 2020 Feb 4;12:133-41. doi: 10.2147/CLEP.S232540.
- Lin KJ, Glynn RJ, Singer DE, Murphy SN, Lii J, Schneeweiss S. Out-of-system Care and Recording of Patient Characteristics Critical for Comparative Effectiveness Research. Epidemiology. 2018;29(3):356-63.
- Lin KJ, Singer DE, Glynn RJ, Murphy SN, Lii J, Schneeweiss S. Identifying Patients with High Data Completeness to Improve Validity of Comparative Effectiveness Research in Electronic Health Records Data. Clin Pharmacol Ther. 2018;103(5):899-905.