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Best practices & select publications

Data linkage to improve causal analyses with secondary data
Identifying Patients with High Data Completeness to Improve Validity of Comparative Effectiveness Research in Electronic Health Records. ​Lin KJ, Singer DE, Glynn RJ, Murphy SN, Lii J, Schneeweiss S. Clinical Pharmacology & Therapeutics - 2018;103(5):899-905.

Out-of-system Care and Recording of Patient Characteristics Critical for Comparative Effectiveness Research. Lin KJ, Glynn RJ, Singer DE, Murphy SN, Lii J, Schneeweiss S. Epidemiology - 2018;29(3):356-363.
confounding control methods
Using Super Learner Predication Modeling to Improve High-dimensional Propensity Score Estimation. Wyss R, Schneeweiss S, van der Laan M, Lendle SD, Ju C, Franklin JM.
Epidemiology -2018 Jan;29(1):96-106.

Relative Performance of Propensity Score Matching Strategies for Subgroup Analyses. Wang SV, Jin Y, Fireman B, Gruber S, He M, Wyss R, Shin H, Ma Y, Keeton S, Karami S, Major JM, Schneeweiss S, Gagne JJ. American Journal Epidemiology - 2018 Mar 15.
index or risk score for patient characterization 
Measuring Frailty in Medicare Data: Development and Validation of a Claims-Based Frailty Index. Kim DH, Schneeweiss S, Glynn RJ, Lipsitz LA, Rockwood K, Avorn J.
The Journals of Gerontology/A Biol Sci Med Sci - 2018 Jun 14;73(7):980-987.

Comparing Approaches to Measure Frailty in Medicare Data – Deficit-Accumulation Frailty Index Versus Phenotypic Frailty. Kim DH, Schneeweiss S, Glynn R.
The Journals of Gerontology/A Biol Sci Med Sci - 2018.
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Validation of a Claims-Based Frailty Index Against Physical Performance and Adverse Health Outcomes in the Health and Retirement Study. Kim DH, Glynn RJ, Avorn J, Lipsitz LA, Rockwood K, Pawar A, Schneeweiss S.
The Journals of Gerontology/A Biol Sci Med Sci -2018 Aug 27. PMID: 30165612.

Resource links

rich clinical data resources
  • Electronic Health Records Research Database (RPDR)
  • Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS)
reproducibility and validity of real-world evidence
  • REPEAT: Evaluating Reproducibility and Robustness of Real-World Evidence
  • RCT DUPLICATE: Building an empirical basis for causal inference methods to replicate randomized trials in real world data
Program of Optimal and Safe Prescribing in the EldeRly (PROSPER)
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Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School


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